Older and very young people may be more susceptible
life-threatening disease and those already suffering from a >> << a weakened immune system. Unfortunately, no one is studying the issue on the spot, so
additional diseases may simply merge with the background of "normal"
health problems in Northeast Wisconsin and Upper Michigan. Infections and cancer is not just the problem. PCBs can also
speed autoimmune disease in which immune system
man turns inward and attacks its own body tissues. (See
autoimmune below) In addition, the immune system influence the development >> << many other systems. The human body is an interconnected network of interdependent systems >>. << Immune system include: bone marrow (in the hollow center of bones
), thymus (located behind the breastbone above the heart
), adenoids, tonsils, spleen (located in the upper left corner of the abdomen
), lymph nodes (lymphatic vessels with >> << concentration in the neck, armpits, abdomen and groin), patches Peyyera (in the gut
), and application. All blood cells of stem cells
live mainly in the bone marrow through a process called hematopoiesis.
Stem cells produce hemotsitoblastov which differ in >> << precursors for all different types of blood cells --- erythrocytes (red blood cells
), platelets (platelets) and leucocytes ( white blood cells
)
Leukocytes are work horses of the immune system. Leukocytes
turn are divided into granulocytes (containing large granules in the cytoplasm
) and ahranulotsity (without granules). Granulocytes consist of neutrophils
(55-70%), eosinophils (1-3%) and basophils (0. 5-1. 0%). Ahranulotsity is
lymphocytes (consisting of lymphocytes and T cells) and monocytes. Lymphocytes circulate in the blood and lymphatic
, system, and make their home in lymphoid organs. During development of the child in the womb, thymus
handles many child lymphocytes that migrate throughout the body >> << blood, seeding lymph nodes and other lymphatic tissue. Basic cell for processing are the T-cells. T-lymphocytes govern cellular immunity
means they help cells recognize and destroy invading bacteria, viruses
abnormal cell neoplasms such as cancer, and foreign tissues. If
thymus does not develop or removed in the early life of the fetus, the immune system
can not develop fully. As a rule, until the baby a few months
old, the immune system already formed so as to function throughout life >>. << However, further growth and development of lymphoid tissue remains
depends on intervention by the thymic cells. After the initial seeding process >> <<, thymus gland secretes a hormone that stimulates further growth
lymphoidal tissue. (Please visit website to learn more about the amazing complexity of the immune system
).
PCBs has been shown to influence thymic function. >> << Persons with reduced thymus gland is prone to get sick often. Infection
become more common and often is chronic and prolonged. Allergy
will be more likely. Other symptoms include swollen glands, depression,
extreme sweating, swelling of the throat. Factors that affect the immune >> << disorders that may affect PCB:
overproductive adrenal glands will produce too much cortisol
and cause thymic and lymphoid tissue to shrink and cause thyroid
thymus. (In many cases after surgery for organ transplants, glucocorticoids
introduced to suppress the immune response, so that our bodies will not be able to recognize the
and refuse foreign tissue).
Enough of growth hormones necessary for the development and function
thymus. Improperly functioning pituitary thus
alter thymic function. Also overactive pituitary gland release too much ACTH
causes oversecretion of cortisol and reduce thymus tissue. PCBs may cause Autoimunnist? The studies included here show that PCBs can be a factor >> << In some autoimmune diseases in PCB exposed people by raising awareness
or other negative immune accessories. About 50 million Americans, 20 percent of the population >> << or one in five people suffer from autoimmune diseases. Women
more likely than men to be affected. It is estimated that 75 percent of the
victims - about 37. 5000000 people - a woman. PCB effects
widespread in the U.S. and even background levels of PCBs have been found
affect the immune system. PCBs may be significantly >> << contribution in this autoimmune and widespread suffering? In organ specific disorders, autoimmune process is
directed mainly to one organ. Examples include
asthma (respiratory system
) Hashimoto's thyroiditis (thyroid gland)
pernicious anemia (stomach), Addison's disease
(adrenal glands) and
,
(pancreas gland). In non-organ-specific disorders, autoimmune activity is widely spread
throughout the body. Examples include allergies
rheumatoid arthritis
systemic lupus erythematosus (SLE or lupus), dermatomyositis
fibromyalgia, and chronic
syndrome fatigue. The immune system normally can distinguish "self" from
"not-I". However, some lymphocytes are able to respond to yourself
by an autoimmune reaction. However, these lymphocytes are usually
suppressed. Autoimmune diseases occur when there is interruption
normal management process, allowing lymphocytes to avoid suppression or
, when there are changes in some tissues, so it is not recognized
. "I", thus attack. The exact mechanisms that cause these changes are not fully understood
, but bacteria, viruses, toxins
(such as PCB?)
And some drugs may play a role in the launch of autoimmune process in
, someone who already has a genetic (inherited) tendency to develop such disorders
He suggested that the inflammation initiated by these agents
toxic or infectious, somehow provokes in the body "sensitivity" (autoimmune reaction
) in the involved tissues. The relationship between hormones and autoimmune
was to conclude with the expression of many autoimmune diseases, and >> << severity of symptoms appears to be related to changes in hormone levels. For example, << >> estradiol (estrogen) is ovaries and effects of nerve cells << >> bones, muscles and other endocrine glands, and metabolism in general. Hormones often secure communication between different systems. For example, << >> estrogen can alter the immune function of cells and also affect the production >> << regulatory factors of immune cells and tissues. PCB << >> hormone mimicry. PCBs may be involved in these processes? Text links --- All the information posted above (except << >> part of the PCB) were found in the web pages listed in lasix 150 mg the section. . << >>