They do not accumulate and bone biopsy ...

Estrogen, calcitonin, and raloxifene are also anti-resorption drugs. They do not accumulate in bone biopsy and bone formation similar to premenopausal levels. Estrogen has been shown to lasix side effects continuously maintain strong bones for 30 years - is the only drug with such a long track record. Estrogen also has been shown to prevent fractures, including hip fractures, a large randomized trial. However, if the combination of hormones (estrogen and progestin) in women starting with ten or more years after menopause, there is an increased risk of cardiovascular disease and breast cancer. In women over 60 who started on estrogen only (without progestin) had no increased risk of cardiovascular disease and breast cancer, but there were more attacks. These risks were not observed in women who were within ten years of menopause. I think it is still advisable to use estrogen in perimenopausal women with bone density at the bottom of 10 to 15% of the population because they have low risk of baseline heart disease or breast cancer and high risk of fractures life.

After 5 to 10 years may be better to switch to another drug, such as raloksifen to minimize the risk of breast cancer that can occur with prolonged estrogen. .